Showing posts with label Halloween. Show all posts
Showing posts with label Halloween. Show all posts

Thursday, October 22, 2015

The Witches In The Rye

The Salem Witch trials remain one of the most haunting chapters in colonial American history. In the winter of 1692, the Puritans in Salem, Massachusetts were facing a terrifying conundrum. For no apparent reason, several young girls started behaving out of sorts.

Contrary to what you might see in the movies, the Salem witches
were not green and they failed miserably at broom flying.
These girls were having unusual fits. One minute they would be ranting incoherently and the next they would regress into a trance-like state (not unlike some candidates in political debates). After the doctor could find nothing wrong with the girls, the obvious conclusion was…witchcraft. 

The finger-pointing quickly commenced - who was responsible for bewitching these girls? But it wasn't easy to spot the guilty parties - it's not like they parked a broom outside the general store or asked for help getting a big black cauldron through their front door. 

The town was whipped up into an historic frenzy and, within a few short months, nearly 200 people were accused of being a witch and 19 of them tragically hanged. The mysterious events disappeared almost as quickly as they came and did not return.

The winter in Salem, 1692, was particularly grim. In addition to battling the cold and hunger, one had to be careful to avoid being accused of witchcraft.
While many people are quick to attribute a mystery to supernatural forces, Linnda Caporael was not content with this explanation. In the 1970s, as Caporael studied the firsthand accounts of Salem’s citizens, she hypothesized that a neurological toxin may be at play.

Caporael recalled that in 1951, the denizens of a small town in France suffered an outbreak of unusual behavior that was linked to ergot poisoning. Ergot is a fungus that grows on rye grain and contains alkaloids such as lysergic acid, the precursor of the psychoactive drug LSD. The strange behavior of the young girls may have looked like witchcraft to someone under the influence of ergot. 

No, “ergot on rye” is not the name of a sandwich you can order at the local deli. These dark areas on the grain are a fungus that may have initiated the Salem Witch trials.
There is little debate that ergot poisoning can cause hallucinations, but is it plausible that the terrible events in Salem had something to do with this fungus? We can’t know for sure, but several lines of evidence are consistent with Caporael’s theory.

Rye grain was indeed the staple crop used to make the bread back then. 1691 was a very warm and wet year for Salem, which would have provided an ideal climate for ergot to flourish. The contaminated rye would have been harvested in the fall to bake bread in the winter, in line with the start of the outbreak just after the New Year.

The ergot poisoning hypothesis also explains why the witch hysteria failed to rear its ugly head again. The following season was very dry, which is not conducive to the growth of the fungus, leaving the rye untainted in 1693.

The ergot theory is not without its problems, as spelled out in this paper. In addition, many scholars highlight the tense atmosphere in Salem at the time. Accusations of witchcraft may have had more to do with rivaling families than anything else.

Contributed by: Bill Sullivan, Ph.D.

Caporael LR (1976). Ergotism: the satan loosed in Salem? Science (New York, N.Y.), 192 (4234), 21-6 PMID: 769159

Friday, October 31, 2014

The Friday Five – Halloween edition

Highlighting some of the coolest science news we’ve seen lately...Halloween edition!

1. Are ghosts real? Science says there’s not a ghost of a chance!

The scariest thing about this scene:  the paucity of channels on the TV.

2. Looking for a way to merge your love of physics with trick or treating? Check out these physics-themed Halloween costume ideas.

This Halloween, go as anti-matter!
 
3. We have nothing to fear but biochemistry. The American Chemical Society has released a neat little video about the chemistry of fear.


 

4. Ever wonder what would happen if you could cross a panda and an owl? A bird with a baboon? Here is a collection of eerie animal hybrids generated with a little help from Photoshop.

The Pandowl

5. Here’s how to make some creepy Halloween decorations from the comfort of your own haunted house!



Science quote of the week:

“Back off, man! I'm a scientist!” –Peter Venkman, Ghostbusters

Contributed by:  Bill Sullivan
Follow Bill on Twitter: @wjsullivan

Tuesday, October 21, 2014

Not Quite Dead Yet

Miracle Max had his own methods for determining if
someone was all dead or just mostly dead. They involved
a bellows and Carol Kane’s voice.  But the point is made,
for centuries, people were just guessing if others were
really dead. There were few experts, and they were
probably just comedians in make-up.
Halloween has morphed into a holiday where people see how much it takes to scare themselves. Horror movies, haunted houses, dangerous pranks; people like to be scared.

What scares you the most– spiders, public speaking, death? These three are high on every list of common fears, but it wasn’t so long ago that another fear was in first place – taphophobia. Never heard of it? I bet that its mere definition will be enough to send a chill up your spine.

Technically, taphophobia means “fear of graves” (taphos = tomb, and phobia = fear of), but its common use is “fear of being buried alive.” Premature burial is not an urban legend, incidents have been documented in nearly every society – and not all of them were just in the movies or books.

In the 1800’s and earlier, being dead was a lot like being a duck….. you know, if it looks like a duck, walks like a duck, and quacks like a duck….. The appearance of death was often enough to make a diagnosis and start going through their pockets.

As a good example of the wisdom of the age, George Washington had these last words, "Have me decently buried, but do not let my body be put into a vault in less than three days after I am dead…….., tis well." He wanted a sufficient amount of time to pass to ensure that he was in fact dead.

The Irish wake probably originated in the leaving of the
tomb unsealed for several days, just in case the dead
person might wake. Later, stories came about concerning
the lead in pewter tankards from which the Irish would
drink. Lead poisoning could induce a state that resembled
death. Sometimes, a wake is just another reason to raise
a glass of ale.
Many cultures built time delays into their death rites to make sure someone was truly dead. Greeks washed the dead….. and some would wake up. In more difficult cases, they would cut off fingers or dunk the bodies in warm baths. The custom of the Irish wake began with the Celts watching the body for signs of life. But mistakes were made, often in times of epidemic..... or because they were drunk.

The hopes of preventing the spread of infection often lead to burying the dead before they were quite dead. I give you plague victim Eric Idle in Monty Python’s Search for the Holy Grail – “But I’m not dead yet…. I’m feeling much better.”

In an effort to see how bad the situation was, the English reformer, William Tebb, in 1905 made a study of accidental premature burial. Tebb was quite the joiner; the weirder the society, the more he wanted to join or lead it. He worked with the Vegetarian Society, the anti-vivisection movement, the national Canine Defense League, and formed National Anti-Vaccination League in 1896.

William Tebb’s book on premature burial was a best seller.
You’d think he had a product to sell given the way he
described some of the incidents. In one, Madame Blunden
was buried in a crypt under a boys school. The next day, the
students heard noises from below. They opened the tomb
and coffin just in time to see her die from lack of oxygen.
In his book, Premature burial, and how it may be prevented, with special reference to trance catalepsy, and other forms of suspended animation, Tebb professed that he had found 219 cases of near premature burial and 149 live burials. He had some stunning stories of scratches on the lids of coffins and noises from newly filled graves.

In her 1996 book, The Corpse: A History, Christine Quigley documents many instances of premature burial and near-premature burial (I LOVE the title). Skeletons were outside their coffins, sitting up in the corner of their vault after being opened years later. Others were found turned over in their caskets, with tufts of their own hair in their hands.

How might this happen? What conditions might make it look so much like you were dead that even your loved ones would let them plant you in the ground? The list is long and varied, but here are some of the more common things that can make you look dead:

Asphyxiation – anything that cuts off your supply of air can make you look dead once you fall unconscious – continuation of this condition leads to actual death. You look dead enough and won’t respond to external stimuli, so people assume you are dead. Close the coffin lid, and soon you really will be dead of asphyxia.

Catalepsy – Many things can bring on this catatonic state in which the muscles are rigid (like rigor mortis after death) and no pain is enough make you respond, one example is epilepsy. Hypnotists call their trances catalepsy (Greek for to grab and take down), but true catalepsy is much more severe and can last hours to days. Severe emotional trauma can also bring it on, so you can certainly be scared enough to look like you are dead.

Catalepsy is denoted by muscle rigidity, so it can look like
rigor mortis. But there is also waxy flexibility in some cases.
The dead-looking not dead people can be posed, and they
will hold the pose indefinitely. What little girl wouldn’t love
a cataleptic doll for Christmas!
Coma – In medicine, a coma is unconsciousness that lasts more than six hours and from which a person cannot be roused and will not respond to stimuli. Injury or inflammation of the cerebral cortex and/ or the reticular activating system in the brain stem can lead to coma. The things that can injure these structures are myriad, from traumatic injury, to drug overdose, to stroke or hyperthermia, etc.

To show how medicine has changed, there is now a battery of assessments called the Glasgow coma scale (GCS) that are carried out on coma victims to assess their state and prognosis. In centuries past, you might look at them, hold a mirror under their nose, maybe lift and drop an arm….. bury them.

The GCS has traditionally been used in the hospital environment, but new evidence shows that a prehospital GCS (assessment at scene or in route) can be just as accurate and may benefit treatment choice in pediatric traumatic brain injury patients. The study compared prehospital and emergency department GCS scores and showed that they were similar. They also compared outcomes with prehospital scores and showed a positive correlation. If assessment and treatment can be begun earlier, outcomes should improve.

Apoplexy – this not a very accurate term any longer, and has meant different things at different times. It can refer to bleeding within an organ or bleeding during a stroke. A stroke is very likely to leave survivors that look like they are dead, and are unresponsive. Nevertheless, there are stroke victims who regain consciousness.

Due to the above conditions, many people in the 1700’s and 1800’s made a hunk of change by promoting safety coffins and vaults. These might be as simple as attaching a rope to the hand of the deceased, and running this rope to the surface where it was attached to a bell.

In other coffins the alterations were more elaborate. There might be glass plates to view the face of the dead or a periscope to keep an eye on the corpse. Some thirty designs were patented just in Germany in the second half of the 19th century, including some that contained vibration sensors, and later… a telephone line.

Waiting mortuaries were built in the 1800’s, mostly in
Germany. Since the best sign of death was the beginning
of the rotting process, these mortuaries were basically
holding cells for bodies while nature took its course. If they
didn’t start to smell, they had to look for fangs or a way to
arouse them.
To be successful, those folks above ground must have been very alert. A coffin has only about 20-40 minutes of air, so a person could go from dead to live to dead without the change being noted. To counteract this small window of time, Germany also built waiting mortuaries, where dead bodies could be held for longer periods of time. It came to be accepted that the only reliable sign death was putrefaction --- waiting mortuaries did not smell like flowers or fresh baked bread.

Modern EEG and EKG have reduced the chance of premature burial or cremation, but mistakes do get made. In 2007, a Venezuelan man awoke during his own autopsy, and Quigley also writes of several modern instances of near-premature burial. Furthermore, the need for quick burial during epidemics has been replaced by the need for timely organ harvests – maybe they aren’t done with that kidney yet!



Contributed by Mark E. Lasbury, MS, MSEd, PhD
As Many Exceptions As Rules



Christopher Dibble (2010). The Dead Ringer: Medicine, Poe, and the fear of premature burial. Historia Medicinae

Nesiama JA, Pirallo RG, Lerner EB, Hennes H. (2012). Does a prehospital glasgow coma scale score predict pediatric outcomes? Pediatr Emerg Care. DOI: 10.1097/PEC.0b013e31826cac31


Thursday, October 16, 2014

Blood. It’s What’s For Dinner.

Halloween will soon be upon us, and our streets will once again be filled with ghosts, zombies, Lady Gagas, and other terrifying creatures of the night. And you can “count” on seeing a few vampires as well, lurking through the shadows in search of blood.

Okay, so maybe not all vampires are scary. If you have trouble sleeping Halloween night, check out this movie and “howl” with laughter.
The practice of feeding on blood, known as hematophagy, is actually a lot more common than you might realize. A wide variety of creatures suck blood, including bats, ticks, leeches, vampire finches, politicians, and so on. Similar to milk, blood is an easily accessable liquid meal containing many proteins and lipids – it does a body good. Many people who are not undead also consume blood, either directly or cooked in foods like sausages, pancakes, and soups. As seen on an episode of the hit reality TV show, Survivor (Africa), the Maasai of Tanzania get their blood straight out of the tap. They cut the neck of cattle just enough to collect blood to make a milk-blood cocktail, and then allow the wound to heal for another drink in the future.  


But not all creatures can easily digest blood. Plasmodium, the single-celled parasite that causes malaria, had to evolve some clever strategies to deal with the toxic byproducts that accumulate during the breakdown of hemoglobin, the oxygen-carrying molecule that comprises approximately 96% of the red blood cells’ dry content by weight in mammals.


(a) The malaria parasite is injected into the host’s bloodstream by another bloodsucker, the mosquito. (b) Sporozoites migrate to the liver and develop into merozoites that invade red blood cells (c). (d) Gametocytes then develop in red blood cells that can be taken up by another mosquito, which will bite a new host to continue the cycle. Life cycle image from: http://www.nature.com/nature/journal/v462/n7271/full/462298a.html   

While in the red blood cell, the parasite replicates like mad. That feverish replication requires a lot of raw materials, like amino acids to build new parasite proteins. Fortunately for the parasite, those red blood cells are rich in hemoglobin, which can be broken down into amino acids the parasite can use. However, as any malarial parasite (or Dr. Dan Goldberg) will tell you, the digestion of hemoglobin is not trivial. As the parasite’s enzymes break it down, the free heme molecules that are released as by-products within the parasite’s food vacuole are highly toxic. If these heme molecules are not disposed of properly, the parasites would die in their own waste.

Bloodsucking humans have an enzyme called heme oxygenase, which can degrade toxic heme; so unlike the malaria parasite, vampires do not need to worry about heme toxicity. But they do have trouble keeping their teeth clean!

So how does Plasmodium solve this problem? If heme were lemons, hemozoin would be the lemonade. The parasite neutralizes the toxic heme subunits by sticking them together into an inert crystal structure called hemozoin. Hemozoin crystals are non-toxic and provide decorative conversation pieces to dress up the parasite’s food vacuole. Probably looks a lot like Shirley MacLaine’s house.

Hemozoin crystals formed within the food vacuole of the malarial parasite.

Incidentally, the process of building hemozoin turns out to be an Achilles’ heel for malaria, as a number of antimalarial drugs work by interfering with hemozoin formation. Unfortunately, the malarial parasite is remarkably adaptive and has evolved multiple ways to become resistant to several drugs in this family.

Contributed by:  Bill Sullivan
Follow Bill on Twitter.


Goldberg, D. (2013). Complex nature of malaria parasite hemoglobin degradation Proceedings of the National Academy of Sciences, 110 (14), 5283-5284 DOI: 10.1073/pnas.1303299110

Gorka AP, de Dios A, & Roepe PD (2013). Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities. Journal of medicinal chemistry, 56 (13), 5231-46 PMID: 23586757