Wednesday, July 18, 2018

If Parasites Had Dating Profiles

Once upon a time, before the Internet, people actually had to venture outside to find a significant other. Popular places to find a potential mate included bars, dance clubs, dog parks, cafes, parties, and the gym. You’d have to work up the courage, and perhaps a cringe-worthy pick-up line, to ask another person out on a date. After an overpriced dinner and movie, you’d have to engage in lengthy conversation under a starry sky to learn about them.

But who has time for all that?! These days, you can simply screen dozens of candidates by reading their dating profiles on matchmaking web sites or apps like Tinder. This modern form of mate selection is unique to humans; imagine if other creatures in the natural world, like parasites, had to write dating profiles…

Toxoplasma gondii

Hanging with my BFFs in a tissue cyst.
We call ourselves "The Brady Bunch"!
Photo by David Ferguson (via EurekAlert)
Do you love cats? So do I! They’re my favorite animal, although I can weasel my way into any vertebrate animal that I want to, including weasels. That’s one of the reasons why I’m called “the most successful parasite on Earth.” I’m the clever parasite that has learned to manipulate the brains of rodents so that they become fearless morons around felines. Normally, mice and rats scurry away from the scent of a cat, but not when I’m in their head!

What turns me on? Long, romantic walks through the hollows of a cat’s innards. I like to groove under the moist sheets of their intestinal epithelium to the musical stylings of Cat Stevens. If we have kids, I promise to be a good parent and read Calvin and Hobbes to them all night long. I’ll be sure to kiss them goodbye before sending them out into the world to contaminate litter boxes, sandboxes, gardens, yards, and streams. Before long, our progeny will be inhaled or ingested by unsuspecting animals.

When I get into something that is not a cat, I get bored rather quickly and go to sleep. You can call me bradyzoite when I’m napping. Life in my intermediate host isn’t all that bad. I can pick pretty much whatever cell type I want and make it my room. The neurons in the brain are ideal because the pesky immune system tends to leave that organ alone, so I get plenty of peace and quiet. I just chill and wait for that animal to get eaten, hopefully by a cat so I can get my groove on again! What if another type of animal eats me instead? No biggie. I’m a patient parasite and will simply wait it out in another intermediate host.

Like I said before, if I landed in a rodent I know how to scramble their tiny brains to increase their chances of getting eaten by a hairball-coughing feline. The human brain is a tad more complex and taking me a little longer to figure out. While knocking around in a human head, I might have increased the risk of some people to develop schizophrenia or rage disorder. But ultimately, I’m trying to rewire the human brain so they leap into lion cages at the zoo.

In my spare time, I love to devour books instead of organ meat. My favorite books include Cat’s Cradle, The Pink Panther, The White Tiger, and of course The Cat in the Hat. I’m also writing my own book. It’s called If You Give A Mouse Toxoplasma…

Schistosoma mansoni

Come swim with Schisto!
Escargot, anyone? My name is Schistosoma, but you can call me Schisto. I live in parts of South America and the Caribbean, Africa, and the Middle East. I hope you don’t think I’m being too fresh, but I’d love to start our date by skinny dipping in my favorite freshwater lake. After we’re done frolicking in the water, we’ll sneak into some snails and develop into cercariae. What? You’ve never been a cercariae before? Have no fear, my darling, I will teach you how to become one. Once we’re cercariae, we’ll break out of the snail and search for the definitive stop on our romantic adventure: an unsuspecting human swimming in our waters.

The cool thing about becoming cercariae is that we’ll look like a mermaid. We’ll gain a gorgeous forked tail that will help us swim around and find a suitable human to invade. I like to hum the theme to Jaws as I make my approach to the human creature! Do you know how many people are attacked by sharks each year? Only 75. I've infected well over 200 million people, but sharks get the scary theme song...go figure!

I think you’ll be surprised how easy it is to burrow into a human's skin – I prefer to enter through a hair follicle. They don’t feel a thing. Once we get inside a human, we can ditch our tails and I’ll give you a grand tour. After a few days gallivanting through the skin, we’ll hang out in the lungs, go through the heart, and then enjoy a bloodmeal as we take a ride in the circulatory system to the liver. This is the stop I find most arousing, and I’ll ask you to pair-bond with me. If you accept, we’ll celebrate by making our way to the veins draining the colon.

Why the veins of the colon? I’m glad you asked, my pet! You see, the colon is where the human stores his waste until he can’t hold it in any longer. We can easily send our eggs into his colon, giving our kids a free ride back out into the water so they can find snails of their own one day. It’s a strategy not unlike the one used by Han Solo in The Empire Strikes Back when he evaded the Star Destroyer by making it appear his ship was just a part of the Imperial garbage.

I think you’ll find that the chemistry between us is no fluke, but rather truly meant to be.

Trypanosoma cruzi

Come cruzi with me! I'm the cute wavy purple things!
Photo: Wikipedia Commons
What could be more romantic than a date that involves a “kissing” bug? That is where our enchanting evening shall begin. From inside the so-called kissing bug, we will watch it latch onto human flesh and suck its blood – cool, huh? After the kissing bug has its fill, it gets the urge to go to the bathroom, using the tiny wound it made as a toilet. That will be our cue to exit: out of the kissing bug, into the human – right through that convenient little hole the bug made in its flesh.

Once under the human’s skin, we’ll transform from trypomastigotes into amastigotes while inside the host’s cells. I hope you don’t think I’m being too prudish, but I’m really not all that into sex. I’d prefer that we multiply on our own, but how about this…we can watch each other divide!

After we make clones of ourselves, there will be too many for the host cell to hold. I just love it when a host cell pops, don’t you? As trypomastigotes again, we’ll be free floating in the blood, where we will hitch a ride when the next hungry bug comes along to “kiss” our human host.

I just hope the kids we leave behind don’t cause trouble. Most of the time when I go through a human, my kids get all rowdy and start having a bunch of kids of their own. The extensive damage they leave in their wake can cause serious problems for the human host, which they call Chagas disease.

While waiting for a kissing bug to pick me up, I enjoy listening to music. Some of my favorite songs include Kiss Me Deadly, Love Bites, and Blow Me (One Last Kiss).

Plasmodium falciparum

I'm a little camera shy, but I like these plushies of me
as they show my softer side!
Photo: Giant Microbes
If you have a fetish for vampires or other blood-sucking creatures, I am the parasite for you! My name is Plasmodium, but most people know me as malaria, which means “bad air.” I hasten to clarify: I do not suffer from flatulence or rancid breath. Before people realized I was a parasite, they attributed the cause of malaria to breathing in “bad air.”

Two of my favorite things in life are blood and sex. I use humans for blood and Anopheles mosquitoes for sex. You might not think that there is enough room in the gut of a mosquito to have a lot of great sex, but give me a chance and I’ll show you that size isn’t everything. After the love making, we’ll take a lovely stroll up to the mosquito’s salivary glands and take a little nap before dinner. While we’re in the salivary glands, you can call me sporozoite.

The mosquito will be our limo to a fine human restaurant where the blood flows like wine. We will get our wake-up call when the mosquito bites a person; then hang tight while we take an exhilarating slide down her proboscis and into a red river. After a quick pit stop in the liver to transform into merozoites and put on our bibs, we’ll jump back into the red river and take our pick at which blood cell we’d like to dine at first. All the hemoglobin you can eat! We will be the envy of Count Dracula!

In humans, red blood cells carry oxygen around the body, so as we destroy them, our human host will soon feel woozy, suffering from anemia, chills, and fever. But have no fear, as I’ll send out an SOS that changes our victim’s scent to be more attractive to mosquitoes. Before you know it, we’ll be pulled up into a fresh mosquito for some more amore.

I’m also a huge movie buff. My favorite movies are The Mosquito Coast, There Will Be Blood, Jungle Fever, and Red River.

Contributed by: Bill Sullivan
Follow Bill on Twitter.

Friday, February 16, 2018

Can Your Cat Cause Demonic Possession?

Cats are routinely associated with malevolent entities in horror stories. They are the favorite pet of witches and villains, a frequent denizen of haunted houses, and the object of several superstitions. Now doctors have linked felines to demonic possession!

Wait, what?

In a new case study published yesterday in the journal Medicine, scientists in China reported that acute infection with the common parasite Toxoplasma gondii triggered the onset of an unusual autoimmune disease called anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis occurs when the body attacks one of its own brain proteins, leading to bizarre personality changes that mimic the stereotypical behaviors that come to mind when we think about demonic possession.

In this case report, a nine-year-old girl arrived at the hospital with seizures, headache, and vomiting. Then she developed unexplained personality and behavior changes. She tested positive for both anti-NMDA receptor antibodies and recent infection with the Toxoplasma parasite.

Anti-NMDA receptor encephalitis was the subject of the bestselling book, Brain on Fire: My Month of Madness, by Susannah Cahalan. In this memoir, which reads like an episode of Mystery Diagnosis, Cahalan describes her terrifying transformation from a vibrant young journalist to an unrecognizable and violent monster. As her condition progressed, she grew paranoid of others, thought family members were imposters, and lashed out at people. She lost control of her bodily movements, suffered seizures, and spoke in tongues. If you didn’t know better, you’d claim she needed an exorcist. Luckily, a neurologist properly diagnosed her disease and gave her immune suppressant drugs that drove it into remission.

Did Regan have a cat?
It is not clear why some people (mostly women) start making antibodies that attack the NMDA receptors in their brain. Some cases are linked to the development of tumors, especially teratomas in the ovaries. Certain viruses that infect the brain, including herpes simplex virus, have also been linked to anti-NMDA receptor encephalitis. Now it seems Toxoplasma, which also infects the brain, may be a trigger of this haunting disease, too.

Toxoplasma is a devious parasite with a complex life cycle. It is capable of infecting any warm-blooded animal, but can only complete its sexual cycle in the intestines of cats. After infecting a cat, the cat spews billions of infectious parasite oocysts into the litter box (or the environment) for up to two weeks. These oocysts are very sturdy and can last up to two years in the environment, giving them plenty of time to be inhaled or ingested by another animal (including humans). In addition to picking up oocysts from the litter box, garden, or sandbox, we can also acquire the infection by eating undercooked meat or unwashed fruits and vegetables.

Once a person becomes infected, the parasite disseminates throughout bodily tissues, including the brain and heart, and transitions into a latent stage called the tissue cyst. While current treatments can stop the parasite from replicating, no drug exists that can get rid of the tissue cysts. In other words, infection with Toxoplasma is permanent. The thought of having a brain filled with these parasites is disquieting, but most scientists believe the cysts are inert unless the individual becomes immune compromised, in which case the parasites can cause massive tissue damage from unchecked growth.

A growing number of scientists argue, however, that in certain individuals the Toxoplasma tissue cysts are not benign and may cause neurological disorders. One of the better-established correlations is the link between Toxoplasma infection and schizophrenia. Interestingly, up to 10% of schizophrenia patients test positive for anti-NMDA receptor antibodies.
The mechanism explaining how Toxoplasma infection may cause anti-NMDA receptor encephalitis remains to be elucidated. Toxoplasma infection is remarkably common (up to one-third of the global population is believed to carry this parasite), but anti-NMDA receptor encephalitis is rare. For now, the authors of the study advise that clinicians assess the possibility of Toxoplasma infection when evaluating a patient with anti-NMDA receptor encephalitis.

To prevent Toxoplasma infection and minimize your chances of becoming possessed by this parasite, be sure to thoroughly cook meat and wash produce and veggies. Wear gloves and a mask when gardening and keep sandboxes covered when not in use. You cannot catch Toxoplasma by petting your cat, but it is important to clean the litter box promptly and wash your hands with soap and water. Pregnant women, in particular, should heed these warnings as infection during pregnancy can lead to miscarriage or serious congenital birth defects. See the infographic below for more.

Contributed by: Bill Sullivan

Monday, November 27, 2017

Biohacking and DIY Gene Therapy: Revolution or Hi-tech Snake Oil?

Do you want bigger muscles? Want to make those brown eyes blue? Does your memory resemble a slice of Swiss cheese? Well, step right up and let me tell you about biohacking! Lend me your ears…and I’ll tell you how to improve them! With our new do-it-yourself genetic engineering kits, you can change whatever genes you want!

Bio-savvy entrepreneurs are determined to make biohacking a mainstream activity. Companies are emerging that promote DIY gene therapy, so now anyone with an opposable thumb can pipet DNA changes into their bodies, their pesky little sister, pets, or just about any living creature they encounter.
Wouldn’t you like to be a biohacker too? Or is biohacking just the latest incarnation of snake oil?
Josiah Zayner, who earned his Ph.D. in biophysics in 2013 at the University of Chicago, is founder and CEO of a company called The ODIN. The main objective of the company “is to make biological engineering and genetic design accessible and available to everyone.” Some of the products on the site look downright cool. One kit allows users to produce bioluminescent bacteria. Another kit makes fluorescent brewer’s yeast (which can then be used to brew beer that glows under blacklight).

Those products seem benign compared to Zayner’s ultimate objective: selling genetic engineering tools to the masses so they can modify their own genes, or those of other living creatures, in whatever way they want without any oversight or regulatory approval. Zayner has already initiated experiments on himself and encourages others to join him on this wild ride. In the rambling presentation below, Zayner explains over shots of scotch and F-bombs that he wants to crowdsource genetic engineering because he believes it will facilitate innovation. Why let professional scientists have all the fun? Zayner demonstrated how easy biohacking your genome can be by injecting the reagents into his arm during the presentation and distributing free samples for the audience to take home.

Let’s take a closer look at his idea. Zayner is using CRISPR/Cas9, a powerful new tool for gene editing, to disable his myostatin gene (learn about the basics of CRISPR/Cas9 and its application in gene therapy). Cas9 is a DNA-cutting enzyme that is directed to a specific site in DNA by a guide sequence. Myostatin stops muscles from growing, so his plan is to knockout this gene in his muscle cells in hopes that it will make them grow once again. Given his affinity for scotch, a more useful experiment might have been to enhance his alcohol dehydrogenase genes.

There is evidence linking the depletion of myostatin to muscle growth. Mice engineered to lack myostatin have double their normal skeletal muscle mass. CRISPR/Cas9 has been specifically used to knockout myostatin in animal embryos, such as rabbits, and the genetically modified animals grew to have more muscle mass. Moreover, when humans are born with mutations that lead to less functional myostatin, they also have more muscle mass (or, in less pleasant-sounding medical terms, “gross muscle hypertrophy”).

CRISPR has already been used to successfully modify human embryos (none were implanted), but to date, no one has tried CRISPR/Cas9 in a living adult. Zayner’s strategy is to simply inject plasmid DNA that contains the Cas9 gene along with the guide sequence that directs it to the myostatin gene.

Importantly, he’s produced no evidence yet to show that these reagents work in human cells. Ideally, we’d like to see confirmation of the gene modification in a muscle biopsy from Zayner, or proof that his approach works in an adult animal model. At the very least, it would be useful to know whether his system alters the gene in cultured cells.

So, can this really work? There are some formidable obstacles and shortcomings. First, the injected plasmid DNA has to get into the muscle cells. Many would argue that the DNA is likely to be degraded or damaged along the way. There is scarce evidence that intramuscular injection of DNA works, but I did find one study done in mice from 1993 suggesting it is possible, although expression levels of the gene injected in this mouse study varied. Variations in the levels of Cas9 or the guide sequence would certainly affect the outcome.

Nevertheless, let’s pretend some of it gets into a few muscle cells and they make the Cas9 protein and its guide sequence. The next big assumption we have to make is that the guide sequence used actually cuts the myostatin gene. Multiple guide sequences usually have to be tried to find one that works and, as mentioned above, I’ve seen no evidence that this particular guide sequence operates as it should in human cells.

Additionally, you have two copies (alleles) of myostatin, one from mom and one from dad. To knockout myostatin completely, Cas9 would have to cut both alleles. Let’s assume we get that far and both alleles of myostatin are cut. Sometimes cells can repair the DNA cut without incident. For myostatin to be disabled, the cell would have to make a mistake when repairing the severed DNA (which they do, but not all the time). Assuming we jump all these hurdles, that one cell or handful of cells is not likely to produce any noticeable change in muscle mass, especially if only one allele was disabled. Zayner claims repeated injections might overcome this issue, but given the sheer number of cells that would need to be altered to produce a visible effect, the claim seems to be on very shaky ground.

Despite all the caveats, disrupting a gene is actually the easiest application of CRISPR/Cas9. To add or change a genetic sequence, an additional fragment of DNA needs to be incorporated where Cas9 made the incision. And if you wanted to use CRISPR/Cas9 to give yourself wings or eyes in the back of your head, you can forget about that. We are nowhere close to knowing how to do such things.

More alarming, there is risk of dangerous side-effects. While the loss of myostatin will increase muscle size as well as bone mineral density and bone mass, it also leads to spinal disc degeneration and spinal osteoarthritis. Second, there is a risk of infection or an allergic reaction to the injections. Third, CRISPR/Cas9 has been reported to produce so-called “off-target” effects. In other words, the guide sequence sometimes escorts Cas9 to other places in the genome, where it may introduce cuts in genes that were not intended to be destroyed—a genetic equivalent of friendly fire.

There’s also the possibility that the CRISPR/Cas9 plasmid itself could integrate into the genome, again possibly disrupting critical genes. One study showed that DNA injected into mouse muscles persisted for life, cranking out the protein constantly. What would happen if Cas9 continues to be produced in Zayner’s cells for the rest of his life? In the worst-case scenario, it would continue to cut up his DNA indiscriminately. There’s also a study in mice suggesting that DNA injection can accelerate autoimmune responses. Finally, unlike injecting an embryo in which all cells have a high probability of being modified, Zayner’s approach is going to produce mosaic effects. In other words, some cells will be edited, but others will not, which could result in a disfigured arm. Zayner dismisses all of these risks with disquieting nonchalance.
If you don’t want to risk modifying your genome to kill your myostatin gene, you can always buy inflatable muscles to wear under your shirt.
Zayner not only advocates genetic modification of your body, but he also encourages biohacking all of nature. He paints a world where you and your buddies decide to order a pizza one night and, what the hell, genetically engineer a puffin to look like a porg. Eschewing the substantial ethical concerns, he is understating the difficulties surrounding genetic modification of complex animals and the sophisticated equipment and training needed to do it. Below is an excellent TED Talk by Ellen Jorgensen that examines the hyped-up claim that CRISPR/Cas9 is cheap and easy.

There’s no product currently available from The ODIN that could bring on the apocalypse, but it is the principle that concerns many people, scientists and non-scientists alike. Even the most avid science enthusiasts are likely to take issue with providing potential crackpots the tools to screw with the recipe of life. Genetic engineering is exciting and promising, but must be explored with great caution by well-trained professionals following reasonable regulations because there is no way to unscramble this egg.

Biohacking has been banned in several countries, and on November 21, 2017 the FDA updated their web site to state that self-administration of gene therapy is against the law. It seems that Zayner, a self-professed fan of the TV show Survivor, just had his torch snuffed out by government regulators chanting, “The tribe has spoken.”

Contributed by:  Bill Sullivan

Follow Bill on Twitter.

The author thanks Colin Sullivan for research assistance and helpful discussions, and Jason Organ for editing and helpful suggestions.

Thursday, September 14, 2017

Awkward To Awesome: Dr. Ty Tashiro on Communicating the Science of Being Awkward

Ty Tashiro knows awkward. As he charmingly admits in his second book, Awkward: The Science of Why We’re Socially Awkward and Why That’s Awesome, he was no stranger to deviating from the norm. But he soon realized that the same characteristics that make awkward people stick out like a sore thumb also make them stand out in the most amazing ways. Ty’s awkward ways earned him a Ph.D. in Psychology from the University of Minnesota, and then he became an award-winning professor at the University of Maryland and University of Colorado.

Ty Tashiro (photo by Brandi Nicole)

Ty is also passionate about science communication, eager to tell the world about fascinating new work in psychology. His first book was The Science of Happily Ever After, which is a scientific guide to finding everlasting love. His work has been featured in the New York Times, the Washington Post,,, and on NPR and Sirius XM Stars radio. Ty kindly agreed to answer a few of our questions about his latest research into awkwardness and why he decided to write popular science.
Awkward Can Be Awesome!
Sullivan:  In your book, you comically describe several instances where you yourself have felt awkward. Tell us more about the ways that awkward can be awesome.
Tashiro:  I think a sense of levity with one’s awkwardness is helpful for everyone because who hasn’t had a blush-worthy awkward moment that turned into a great story? There’s nothing wrong with being awkward, but it’s helpful for awkward people to understand their unique attributes that can be leveraged to accomplish extraordinary outcomes.
I like to explain what social scientists have discovered about social awkwardness with a spotlight analogy. Imagine that you see life unfold on a stage and that stage is broadly illuminated. You could easily shift your attention as people enter or exit the stage, watch the key interactions at center stage, and pick up on the context around center stage. That’s how most people see the social world.
Awkward people see their stage spotlighted and their sharply focused beam of attention tends to fall a little left of center stage. So, they’re more likely to miss some of the key social information at center stage, but whatever falls under their spotlighted attention is seen with great focus and potentially a brilliant clarity. This spotlighted perspective manifests in behaviors such as intense focus, persistence, and even an unusual level of enthusiasm for the things they love.
There are interesting behavioral genetic and developmental psychology studies that show a moderate, but robust association between social awkwardness and striking talent, which is a way to describe people who show exceptional ability or achievement in a specific area. Although some of this correlation is accounted for by I.Q., the stronger mediator is their obsessive drive to learn everything they can and master their area of interest.

Are Science Nerds Real?
Sullivan:  This certainly doesn’t apply to all scientists, but I know many who would describe themselves as socially awkward. Do you have a sense as to why scientists might be disproportionately awkward?
Tashiro:  Simon Baron-Cohen and his colleagues have been at the forefront of understanding people with social skill deficits, communication difficulties, and the kind of obsessive interest that characterize socially awkward people. In a series of studies, they compared the degree of awkward characteristics among Oxford students majoring in the humanities, sciences, computer science, and a group of high school students involved with their school’s math competitions. What they found was that compared to humanities majors, those students majoring in sciences, computer science, and the matheletes reported significantly more awkward characteristics.
Follow-up studies suggest that people with awkward characteristics tend to think in a more systematic or methodical manner, which is a style of problem-solving that is well-suited to fields like science, computers, or math that employ things like the scientific method or orders of operation.
Awkward people love to take things apart, intensively study how the pieces function, then put those pieces together in a way that makes more sense. In this way, the awkward mind can be advantageous for someone who is passionate about describing, organizing, and predicting phenomena.

Ty Tashiro’s second book, Awkward: The Science of Why We’re Socially Awkward and Why That’s Awesome, examines what it means to be awkward and how those traits also often lead to success.

Antidote for the Esoteric.
Sullivan:  Being socially awkward might hinder one’s ability to communicate research effectively. Do you have any advice for people who fall into that category?
Tashiro:  The risk for any awkward person is to fall too far down the rabbit hole. Researchers are rewarded for being meticulous about details, learning how to effectively use the specific terminology in their subfield, and being hyper-aware of methodological nuances. None of these qualities should be compromised because they are necessary for great science, but it’s also easy to see how the best of us could get so deep into their field of research that they forget what the non-specialist wants to know or needs to know.
Part of the problem is that a great lab usually means that the Principal Investigator manages an army of graduate students, post-docs, and undergraduate research assistants. With the time pressures and publication pressures, the P.I. gets data or results, but begins to lose an opportunity to be hands on.
I remember hearing a story in graduate school about Harry Harlow, who is famous for his early primate studies that showed infant primates preferred a cloth surrogate mother that provided tactile comfort to a surrogate mother that provided food. My professor was an emeritus faculty at Minnesota who told us that the spark for Harlow’s idea occurred while he was cleaning the cages of the primates, a task usually reserved for research assistants. Harlow noticed that the primates resisted when he tried to remove the towels from the bottom of their cages. Harlow’s willingness to immerse himself with his subjects allowed him to see a pragmatic, but revolutionary insight.

Why SciComm? 
Sullivan:  What motivated you to write about science for a broader audience?
Tashiro:  When I was an assistant professor at the University of Maryland, I loved teaching an undergraduate course about the psychology of interpersonal relationships because the students asked incisive, practical questions that often left me speechless or inarticulate. I could walk them through a compelling, programmatic area of research and they would politely ask me, “So what?”
These students wanted to know how evolutionary research applied to their mate preferences on Friday night or how they could apply social psychology studies of persuasion to help a friend out of an unhealthy relationship. My answers were not always satisfactory, so maybe out of stubbornness I decided to tackle the problem of translating great social science into practical advice. While we usually think of translational research as the gap between basic and applied science, my translational task has generally been to bridge the gap between applied research and the general public.

Ty’s Tips for Science Writers.
Sullivan:  What tips can you give aspiring science communicators?
Tashiro:  I’ll start with the bad news, then give you the good news. As I began investigating how to write in a compelling manner for broad audiences, I realized that the cornerstones of great storytelling are rich scenes, complex characters, and brisk plot. Then, I realized that science writing for journals has no scene, character, or plot. Some people might protest that the materials, subjects, and procedures count, but that’s a stretch.
I should be clear that I don’t think science writers should change how they write for journals or their colleagues. There’s a precision and factual nature to good science writing that is valuable and necessary, but it’s a style that does not appeal to broad audiences. So, the starting point for aspiring science communicators is to think about how to infuse scene, character, and plot into the scientific narrative.
My strategy has been to open every chapter with a story that is humorous or mysterious and this story sets up a research problem. In AWKWARD, I set up the descriptive statistics chapter with a middle school mishap involving awkward all-star wrestling re-enactments that ended with me concussed. I set up the social neuroscience chapter with a story about my first middle school slow dance that left readers wondering whether the boy should kiss the girl.
Both stories are absurd, mildly embarrassing for me, but they allow me to get readers invested in a character who needs to solve a conundrum. The middle parts of my chapters give readers research findings that help them piece together clues about why I ended up concussed or whether I should go in for the kiss. I end each chapter by giving the reader the outcome from the opening story, which allows me to summarize the data through the lens of a character trying to take appropriate action on a scene.
For researchers in physics, biology, or other fields that do not always involve human subjects, you sometimes end up anthropomorphizing molecules or species, but this can provide a wonderful opportunity for fanciful, unexpected storylines.
As science comes under siege these days, it’s more important than ever for the science community to cooperate and find a way to captivate the broader public with science and to share the wonderful discoveries you’ve observed under your brilliant spotlight.

This article originally appeared on PLOS SciComm Blogs.

Bill Sullivan

Bill Sullivan is Showalter Professor at Indiana University School of Medicine, where he studies infectious disease. Bill has published over 70 papers in scientific journals and written for Scientific American, Scientific American MIND,,, What Is Epigenetics, and more. He also maintains his own popular science blog called THE ‘SCOPE. Bill received his Ph.D. in Molecular & Cell Biology from the University of Pennsylvania.