Tuesday, October 14, 2014

Zombies And The Loss of Free Will

Zombies don’t have a choice in how they behave. Free will
is a thing of the past; they don’t even have the ability to resist
a dance routine with Michael Jackson. Michael seems awfully
at ease in the midst of the undead. Creepy….yes. Scary…. yes.
A thriller?…..maybe no.
I have a hard time believing that zombies eat brains because they taste so good. It's more likely that they don’t have a choice; their activities are decided for them. They’ve lost their free will. Isn't that sort of the definition of a zombie - no free will?

Don’t scoff at this; nature is full of examples where one organism can cause another organism to change its behavior – just think of all the silly things boys do trying to impress girls. But first a couple of stories where a change in behavior has less to do with parasitism.

In August 2013, residents of Moscow began reporting that the pigeons were acting odd. They would walk around in a funk, not get out of the way of traffic, and not fly away from danger. One family reported that their dinner one evening was disrupted by a pigeon on their window ledge that lost its balance and fell into their kitchen.

These zombie pigeons (The Pecking Dead, as one website called them) were freaking out the population, so the scientists went to work. It seems that many of the dead and affected pigeons were carrying salmonella bacteria and/or had Newcastle disease. The virus that causes this disease, unimaginatively called the Newcastle disease virus (NDV), can be transmitted to humans, so it's a good thing the population got freaked out.

The virus causes the birds to stagger about, stumble around in circles, and turn their heads upside down – much like vodka does in humans. However, when humans get NDV, they most likely will just have a flu-like episode.

Zombie birds also led to a famous movie. Alfred Hitchcock’s classic film, The Birds, is the story of a terrifying attack on a small fishing village by many flocks of different birds. They attacked people, flew into car windows and houses, and caused deaths and damage. Seems silly doesn’t it, being killed by a shore bird? I think I would have them give some other reason in my obituary.

Tippi Hedrin was the female lead in Hitchcock’s The Birds. Hitch
had seen her in some commercials and chose her over Grace
Kelly….. GRACE KELLY! Later on, he developed an unhealthy
obsession with Tippi, and who wouldn’t, with all that running and
screaming and bird doo?
It turns out that the movie was based on a 1961 incident near Monterey Bay, California. The birds went nuts and no one knew why – that makes it creepier. It wasn’t until 1995 when another episode of bizarre behavior in sea lions led to the answer.  The sea lions in 1995 and 2010-11 were acting like zombies as well. They wouldn’t get out of the way of boats or they would come up on land and just keep scooting inland until they died.

In 1987, it was recognized that a toxin produced by certain species of marine algae was responsible for the zombie like behaviors. Called domoic acid, the toxin is produced by the algae and accumulates in marine organisms that feed on phytoplankton or algae that are contaminated. Normally, levels of domoic acid are too low to cause problems, but in years where the algae overgrows, called a bloom, the levels will rise dramatically.

Although the acid seems to have no affect on lower life like shellfish, bigger animals are strongly affected, including humans. When the sea lions or birds feed on contaminated food, they begin to display the bizarre behaviors. In the case of the 1961 birds, there happened to be a collection of samples from the bay that had been kept all these years. Tests on the shellfish and algae samples from 1961 showed high levels of domoic acid.

Is there free will in lower animals?  You betcha. Most people believe that the behaviors of insects and such are merely responses to environmental and situational cues, and any variation in behavior is due to misreading of cues or random errors. But studies in fruitflies show that they can pick out their own patterns of behavior when a blank canvas is given them.

The Emerald Cockroach Wasp (A. compressa) is solitary insect,
it doesn’t live communally as many bees and wasps do.  Only
the females have stingers, so making zombies is definitely a
reproductive strategy. In 1941, they were introduced to
Hawaii to try and control the cockroach population, but it
didn’t work. They just don’t lay enough eggs.
One such case of co-opted free will in an insect is the Jewel Wasp (Ampulex compressa) and the American Cockroach (Periplaneta americana). The wasp lives in Africa and Asia, so this isn’t something we could use to get rid of NYC cockroaches. P. Americana isn’t even native to the Americas. It was introduced from Africa as early as 1625, before it was officially named.

What the wasp steals is the roach’s ability to decide if it wants to walk or run. Most wasps sting to kill, but the Jewel Wasp stings the cockroach in the brain, altering its behavior with its venom. A 2010 study showed that the wasp stings the roach continuously for up to three minutes, trying to locate a particular part of the cockroach’s brain.

What it is searching for is called the subesophageal ganglion, the part of the brain that allows the roach to initiate walking and running movements. When that part of the brain is flooded with venom, the cockroach stands still, with no will to begin leg movements. It isn’t paralyzed – it’s just a zombie.

Another study has started to investigate just how the wasp venom robs the cockroach of its will to walk. There is an insect neurotransmitter called octopamine that is released by some of P. Americana’s neurons. It is this transmitter that allows the cockroach to initiate walking.

The study hasn’t pinpointed just how the venom interrupts the octopamine signaling, but they know if they deplete the amines in the brain, they see the same affect. If they add back octopamine, they can rescue the cockroach’s natural behavior. However, the study also showed that the venom doesn’t reduce octopamine levels and it doesn’t prevent is release, so there's still more work to be done.

The wasp first stings the cockroach in the abdomen, just a
quick sting to temporarily weaken the front legs. Then it
stings the brain and when the cockroach stops
moving, it cuts off part of one antenna. I don’t know why. It
grasps the antenna in its jaws and herds to the roach to its nest.
Instead of pulling, they should evolve saddles.
Why does the wasp turn the cockroach into a zombie? I’m glad you asked. Remember, the cockroach isn’t paralyzed, it just hasn’t the will to walk on its own. So the wasp tugs on the cockroach’s antennae and herds the roach into its underground nest. There the wasp lays an egg in the cockroach’s abdomen and the emerging larva feeds on the cockroach until they are ready to emerge eight days later.

So why not just kill the cockroach with the sting and lay the egg? The larva need fresh meat, and a dead cockroach rots in one day. To make the meal satisfactory for the eight days needed, the cockroach must remain alive, but in a state where it can’t attack the wasp or the larva; hence the zombification.

It gets even creepier. The wasps have gotten so good at this strategy that they now go to the trouble of cleaning their meal. A 2013 study shows that the wasp larvae produces several antimicrobial chemicals that rid the cockroach of any contaminating bacteria or parasites as the larvae munch on it. I know I’d clean a zombie before I ate it.

Contributed by Mark E. Lasbury, MS, MSEd, PhD
As Many Exceptions As Rules

Banks CN, & Adams ME (2012). Biogenic amines in the nervous system of the cockroach, Periplaneta americana following envenomation by the jewel wasp, Ampulex compressa. Toxicon : official journal of the International Society on Toxinology, 59 (2), 320-8 PMID: 22085538

Herzner G, Schlecht A, Dollhofer V, Parzefall C, Harrar K, Kreuzer A, Pilsl L, & Ruther J (2013). Larvae of the parasitoid wasp Ampulex compressa sanitize their host, the American cockroach, with a blend of antimicrobials. Proceedings of the National Academy of Sciences of the United States of America, 110 (4), 1369-74 PMID: 23297195


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